History of Regenerative Therapy

History of Regenerative Therapy

by Yenny (SU)

Back in 1992, Dr. Leland Kaiser coined the term "regenerative medicine" in an article on hospital administration. He referred to it as "a new branch of medicine … that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.”

Although it may seem as if regenerative medicine is a product of 21st century ingenuity, it is, in fact, an evolving form of treatment that can be traced all the way back to the ancient civilizations of Sumeria, Egypt, China, India, and South America.

In fact, here are some of regenerative medicine’s historical milestones:

Ø  In the 1st century CE, Roman doctor Celsus recorded his discovery of the four signs of inflammation – heat, pain, redness, and swelling.

Ø  Skin graft procedures for facial reconstructions were recorded by Suhruta, an Indian physician, over 1,000 years ago.

Ø  In the early 16th century, surgeons Cosmas and Damian pioneered tissue grafting.

Ø  In the late 1700’s, German physiologist Caspar Friedrich Wolff studied chick embryos and proved that development occurs in a series of epigenetic steps (modifications of DNA).

Ø  The fields of biology and medicine underwent a huge expansion in the early 1800’s when scientists discovered that all life depends on chemical reactions that occur within cells … and that these cells could be reproduced in a laboratory.

Ø  In 1882, German biologist Walther Flemming discovered cell division and heritability in the form of DNA.

Ø  In the mid-1950s, work in the field of transplantation led to the first therapeutic surgeries, starting with the first kidney transplant in 1954. That was followed by the first liver and lung transplants in 1963, the first pancreas transplant in 1966, and the first heart transplant in 1967. Soon, bone marrow transplant for the treatment of leukemia became a reality.

At that point, cell biologists began to focus on the possibility of creating, growing, and harvesting tissue in the laboratory. And so began the era of tissue engineering that has led to regenerative therapy.

Today, this promising field of regenerative medicine is working to restore structure and function of damaged tissue by promoting healing and cell regrowth, many times without surgery. That’s because regenerative therapy uses a patient's own tissues to initiate the healing process. Two regenerative treatments used by Dr. Vic Kalman are stem cell therapy – from his patients’ own natural stem cells – and PRP (platelet-rich plasma) therapy from his patients’ own natural growth factors found in blood plasma. With years of research and application, he has accomplished significant improvement in patient outcomes.  

Dr. Kalman, a board-certified orthopedic surgeon, has seen such positive results from regenerative medicine treatments such as stem cell and PRP therapy that he will often suggest trying these treatments before turning to more invasive surgical options. To learn more about stem cell treatment and how it might be able to help you and your orthopedic conditions, request a consultation with Dr. Vic Kalman by calling (302) 529-5500, to be seen at our office in Wilmington, DE.